Advanced System Design :
- Uses flow resistance and compliance chambers to simulate physiological cardiac preload and afterload
- Provides controlled ex vivo isolated heart conditions
- Simulates peripheral vascular resistance
- Supports studies of normal and diseased cardiac states
- Allows measurement of cardiovascular parameters
- Supports single ECG Lead II and single epicardial monophasic action potential measurements
- Supports pressure-volume measurement of the right and left ventricles
Measured Signals and Calculated Parameters :
- Left atrial preload pressure
- Left ventricular filling pressure
- Right atrial preload pressure
- Right ventricular filling pressure
- Afterload pressure
- Aortic pressure for calculation of systolic and diastolic pressure
- Right ventricular afterload
- Pulmonary artery pressure
- Left ventricular pressure or pressure-volume loops
- Right ventricular pressure or pressure-volume loops
- Cardiac output
- Left atrial flow
- Aortic flow
- Right atrial flow
- Coronary flow calculated from aortic flow and cardiac output or from right atrial flow and pulmonary artery flow
Included Items :
- Biventricular working heart base unit
- Jacketed glass heart chamber with bottom drain
- Thermocirculator with stainless steel bath and lid
- Peristaltic pump
- Multi-channel peristaltic pump
- Tubing set
- Jacketed glass reservoir for buffer solution with frit
- Modular instrument case
- Transducer amplifier module
- Blood pressure transducer
- Venous pressure transducer
- Transducer amplifier modules
Base Unit Includes :
- Plexiglass stand
- Aorta link unit with Windkessel
- Adjustable artificial flow resistance for adjustment of aortic afterload pressure
- Pressure gauge
- Preheating coil for Langendorff mode
- Holder for pressure transducers for aortic and perfusion pressure
- Tubing for in situ preparation with adapter
- Left atrium cannulating system
- Preload reservoir
- Preheating coil
- Movable atrium connection adapter
- Holder for preload pressure transducer
- Column for right atrium cannulation
- Movable right atrium connection adapter
- Holder for right atrium pressure transducer
- Right ventricle afterload system for simulation of lung resistance
- Species-specific cannulae are required separately according to the animal model
Peristaltic Pump Package :
- Pump drive
- Pump head
- Two V-tube bed sets
Required Species-Specific Additions :
- Functional operation requires a suitable species-specific cannula set
- Cannula sets are available for rat, guinea pig and rabbit hearts
Rat/Guinea Pig Biventricular Cannula Set :
- Aortic cannula set for rat and guinea pig hearts, 2.5 mm OD and 3.0 mm OD
- Left atrium cannula, 2.3 mm OD
- Right atrium cannula, 2.3 mm OD
- Pulmonary artery cannula set, 2.5 mm OD with mini-ball joint mounting kit
Rabbit Biventricular Cannula Set :
- Aortic cannula for rabbit hearts, 3.0 mm, 4.0 mm and 5.0 mm OD
- Left atrium cannula, 2.3 mm OD
- Right atrium cannula, 2.3 mm OD
- Pulmonary artery cannula set, 2.5 mm OD with mini-ball joint mounting kit
