Core System Options :
Langendorff Only Configuration :
- Species-specific addition for mouse hearts or rat/guinea pig hearts
- Constant pressure and flow controller for perfusion control
- Suitable for constant pressure perfusion and indirect coronary flow measurement
- Requires a PC-based data acquisition system
Langendorff Working Heart-Ready Configuration :
- Species-specific addition for mouse hearts or rat/guinea pig hearts
- Starling resistor for perfusion pressure control in Langendorff mode
- Functions as an afterload system in working heart mode
- Direct coronary flow measurement is required when coronary flow data is needed
Perfusion Pressure Controller :
Constant Pressure/Flow Controller :
- Maintains perfusion at constant pressure or constant flow using a peristaltic pump
- Provides accurate control of perfusion flow rate or pressure, including at very low flow rates
- Uses pressure feedback to regulate pump-generated flow
- Calculates flow rate from pump speed for indirect coronary flow measurement
- Allows simple switching between constant pressure and constant flow
- Flexible perfusion circuit setup for different experimental conditions
Measured Signals and Calculated Parameters :
- Indirect coronary flow measurement
- Coronary resistance calculation
Additional Requirement :
- PC-based data acquisition system
Starling Resistor Perfusion Pressure Controller :
- Provides constant pressure perfusion in Langendorff mode
- Functions as an afterload system in working heart mode
- Uses a membrane flow resistor, manometer and pressure syringe to create a pressure-controlled valve in the aortic block
- Mechanical system that does not provide flow information or alter pump flow rate
- Excess flow returns to the reservoir through the valve
- Direct coronary flow measurement is required for coronary flow data
Measured Signals and Calculated Parameters :
- Coronary flow data through the flow measurement option
Includes :
- Aortic block base unit with flange-mounted adjustable flow resistance
- Pressure syringe with mounting bracket
- Manometer
Species-Specific Options :
Mouse Hearts :
- Aortic cannula for mouse heart, 1.0 mm OD
- Tubing, 1.22 mm ID, 12 pieces
- Tubing set for jacketed buffer reservoir with fluid line shutoff valves
- Jacketed reservoir for buffer solution with frit, 1 L
- Mini balloon kit for mouse heart
Rat Hearts :
- Aortic cannula for rat heart, 2.3 mm OD
- Aortic cannula for rat/guinea pig heart, 3.0 mm OD
- Tubing, 2.79 mm ID, 12 pieces
- Tubing set for jacketed buffer reservoir with fluid line shutoff valves
- Jacketed reservoir for buffer solution with frit, 2 L
- Balloon kit for rat heart
Guinea Pig Hearts :
- Aortic cannula for rat/guinea pig heart, 3.0 mm OD
- Tubing, 2.79 mm ID, 12 pieces
- Tubing set for jacketed buffer reservoir with fluid line shutoff valves
- Jacketed reservoir for buffer solution with frit, 2 L
- Balloon kit for rat heart
