Flow Measurement Options for Langendorff and Working Heart Modes for Physiology Lab

The flow measurement option provides two methods for measuring flow in functional isolated heart systems: indirect measurement through pump speed control and direct measurement using ultrasound transit time technology. Species-specific flow probes and adapters are required according to the isolated heart system and application. The system supports coronary flow measurement in retrograde Langendorff mode and aortic or cardiac output measurement in working heart mode. Manufactured by Atico Export with a focus on precision, durability and consistent performance for physiological research and experimental laboratory use.

• Accurate coronary flow measurement during drug studies
• Studies of coronary resistance changes before and after ischemia
• Myogenic autoregulation studies
• Reactive hyperemia studies
• Aortic flow measurement in working heart mode
• Cardiac output measurement in working heart mode

Flow Measurement Methods :

Indirect Flow Measurement :

• Measurement by controlling the speed of a roller pump
• Suitable for constant pressure or constant flow perfusion
• Provides accurate control of perfusion pressure or flow, including at very low flow rates
• Calculates indirect coronary flow from pump speed
• Suitable for Langendorff perfusion applications

Direct Flow Measurement :

• Uses ultrasonic transit-time flow measurement
• Provides direct and accurate flow measurement in mL/min
• Suitable for coronary flow measurement in retrograde Langendorff mode
• Suitable for aortic flow measurement in working heart mode
• Requires species-specific flow probes and adapters
• Flow probe is integrated into the perfusion path through a suitable adapter

Constant Pressure/Flow Control :

• Allows perfusion under constant pressure or constant flow
• Provides switchable pressure and flow control
• Provides accurate control even at very low flow rates
• Enables indirect coronary flow measurement from pump speed

Direct Flow Measurement Features & Benefits :

• Accurate ultrasonic transit-time direct flow measurement
• Flow probe integrated into the perfusion path
• Laminar flow paths improve measurement accuracy
• Adapter design helps reduce temperature loss
• Supports studies of myogenic autoregulation and reactive hyperemia
• Direct measurement provides accurate response during changing flow conditions

Required Components :

• Flow measurement controller or flowmeter according to the selected measurement method
• Species-specific flow probes
• Species-specific adapters
• Appropriate core system and core system options

Direct Flow Measurement / Mouse with Small Rodent System :

• Application: Coronary flow measurement in retrograde Langendorff mode or aortic flow measurement in working heart mode
• Flow probe: 1 mm class flow probe
• Adapter for small rodent flow probe

Direct Flow Measurement / Rat with Small Rodent System :

• Application: Coronary flow measurement in retrograde Langendorff mode or aortic flow measurement in working heart mode
• Flow probe: 2 mm class flow probe
• Adapter for 2 mm class flow probe

Direct Flow Measurement / Rat and Guinea Pig with Large Rodent System :

• Application: Coronary flow measurement in retrograde Langendorff mode or aortic flow measurement in working heart mode
• Flow probe: 2.5 mm class flow probe
• Adapter for 2.5 mm class flow probe

Direct Flow Measurement / Rabbit with Large Rodent System :

• Application: Coronary flow measurement in retrograde Langendorff mode or aortic flow measurement in working heart mode
• Flow probe: 4 mm class flow probe
• Adapter for 4 mm class flow probe

Cardiac Output Measurement / Working Heart / Mouse :

• Application: Flow measurement into the left atrium in working heart mode
• Flow probe: 1 mm class flow probe
• Adapter for small rodent flow probe

Cardiac Output Measurement / Working Heart / Rat :

• Application: Flow measurement into the left atrium in working heart mode
• Flow probe: 2.5 mm class flow probe
• Adapter for 2.5 mm class flow probe

Cardiac Output Measurement / Working Heart / Rat and Guinea Pig :

• Application: Flow measurement into the left atrium in working heart mode
• Flow probe: 2.5 mm class flow probe
• Adapter for 2.5 mm class flow probe

Cardiac Output Measurement / Working Heart / Rabbit :

• Application: Flow measurement into the left atrium in working heart mode
• Flow probe: 4 mm class flow probe
• Adapter for 4 mm class flow probe