Reliable & effective in vitro and ex vivo exposure for Physiological Research Instrumentation

The Reliable & effective in vitro and ex vivo exposure for Physiological Research Instrumentation is an in vitro and ex vivo exposure system designed for efficient aerosol deposition onto cells and tissues using thermophoresis. It supports controlled Air Liquid Interface and Transwell exposure studies, with options for real-time dose measurement, flow control, humidity monitoring and temperature control. Manufactured by Atico Export with attention to applicable quality, safety and functional requirements for physiological research and laboratory applications.

• Designed for in vitro and ex vivo Air Liquid Interface (ALI) and Transwell exposure studies
• Efficiently deposits aerosols onto cells and tissues
• Uses thermophoresis to direct particles onto target tissues through a temperature gradient
• Increases particle deposition rates from approximately 2% to nearly 40%
• Supports real-time deposited-dose measurement when integrated with a Quartz Crystal Microbalance (QCM)
• Suitable for integrating in vitro, ex vivo and in vivo exposure models
• Supports optimized compound usage and 3Rs-based experimental approaches

Research Applications & Use Cases :

• Tobacco and cannabis studies
• E-cigarette and vaping studies
• Chronic obstructive pulmonary disease (COPD)
• Microplastic inhalation
• Nebulized drugs and toxins
• Gas, VOC and dry powder exposures

Techniques & Measurements :

• Exposure site control
• Main-flow and micro-flow
• QCM dosimetry
• Humidity measurement and control
• Gravimetric analysis
• Temperature control

Exposure Site Specifications :

• Dimensions (Width × Depth × Height): 200 × 101 × 139 mm (7.87 × 3.98 × 5.47 inch)
• Weight: 3 kg (6.61 lbs)
• Primary flow volume: 11.4 ml
• Micro-flow volume: 0.65 ml
• Exposure unit temperature: 30–55 °C
• Differential pressure: < ±1 mBar
• Input tubing outer diameter: 12 mm
• Output tubing outer diameter: 1/4 inch
• Wetted materials: Teflon, stainless steel, silicon rubber, Buna-N O-rings and nickel-plated brass connectors

Well Plate Options :

12-Well Transwell Inserts :

• 0.4 µm pore size with polycarbonate membrane
• 0.4 µm pore size with polyester membrane
• 3.0 µm pore size with polycarbonate membrane
• 3.0 µm pore size with polyester membrane

12-Well Cell Culture Inserts :

• 0.4 µm pore size with PET membrane
• 0.4 µm pore size with high-density PET membrane
• 1.0 µm pore size with PET membrane
• 3.0 µm pore size with PET membrane
• 3.0 µm pore size with high-density PET membrane
• 8.0 µm pore size with PET membrane

• Accurate and efficient particle deposition profiles
• Physiologically relevant particle exposure
• Optimized workflow
• Thermophoretic particle deposition
• QCM-based real-time dosimetry
• Air Liquid Interface exposure
• Transwell exposure
• Controlled temperature and humidity
• Suitable for in vitro and ex vivo exposure studies