Measured Signals & Calculated Parameters :
- Preload pressure
- Left atrial preload and ventricular filling pressure
- Afterload pressure
- Diastolic and systolic aortic pressure
- Left ventricular pressure
- Pressure-volume loops
- Cardiac output
- Atrial flow
- Aortic flow
- Coronary flow through direct measurement or flow subtraction
Included Items :
- Working heart option
- Blood pressure transducer
- Transducer amplifier module
- Peristaltic pump
Working Heart Option Includes :
- Left atrium cannulating system
- Preload reservoir
- Preheating coil
- Movable atrium connection adapter
- Holder for preload pressure transducer
Peristaltic Pump Package :
- Pump drive
- Pump head
- Two V-tube bed sets
Required Species-Specific Atrial Cannulae :
Rat/Guinea Pig Hearts :
- Left atrial cannula, 2.3 mm OD
Rabbit Hearts :
- Left atrial cannula, 6.0 mm OD
Left Atrial and Aortic Flow Measurement :
- Indirect flow measurement by controlling the speed of a peristaltic pump
- Direct flow measurement using ultrasonic transit-time technology
- Requires suitable species-specific flow probes
Intracardial Left Ventricular Pressure Measurement :
- Allows introduction of a tip pressure catheter directly into the left ventricle through the adapter port and aorta
- Avoids the need for apical puncture
Pressure-Volume Loop Measurement :
- Allows introduction of a pressure-volume loop catheter directly into the left ventricle through the adapter port and aorta
Increased Preload Pressure :
- Used when left atrial preload pressures higher than 11 mmHg are required
Coronary Effluent Collection :
- Supports collection of coronary effluent for metabolic studies and further analysis
- Allows continuous measurement of pO2, pH and pCO2 when suitable components are used
Perfusate Oxygenation :
- Suitable for oxygenation of buffer solutions containing albumin, fatty acids, washed erythrocytes or other foaming additives
Perfusate Filtration :
- Provides filtration of recirculated perfusate
Temperature Measurement :
- Enables measurement of perfusate temperature
- Suitable for specific temperature studies and special temperature protocols such as cooling or transplantation studies
Perfusion Solution Monitoring :
- Continuous or intermittent measurement of pO2
- Continuous or intermittent measurement of pH
- Continuous or intermittent measurement of pCO2
Drug Addition :
- Supports drug addition where flow is measured or calculated
- Suitable when drugs must be added according to a specific flow ratio
Pacing Option :
- Provides pacing for functional Langendorff and Working Heart systems
- Suitable for small rodent hearts including mouse, rat and guinea pig
Single-Lead ECG and MAP Measurement :
- Supports single-lead ECG measurement combined with one MAP electrode
Multi-Lead ECG and MAP Measurement :
- Supports up to 12 ECG leads combined with up to 8 MAP electrodes
- Suitable for rat, guinea pig and rabbit hearts
