Measured Signals & Calculated Parameters :
- Preload including left atrial preload and ventricular filling pressure
- Afterload determining diastolic and systolic aortic pressure
- Intracardial left ventricular pressure
- Pressure-volume loops
- Atrial flow
- Aortic flow
- Coronary flow
Included Items :
- Working heart upgrade
- Pump
- Tubing
- Blood pressure transducer
- Transducer amplifier module
- Jacketed buffer reservoir
- Tube set for jacketed buffer reservoir with fluid line shutoff valves
Working Heart Option Includes :
- Left atrium cannulating system
- Preload reservoir with 2 to 7 ml capacity
- Movable atrium connection adapter
- Holder for preload pressure transducer
- Atrial cannulae must be selected separately
Species-Specific Atrial Cannulae :
Mouse Heart :
- Left atrial cannula, 1.3 mm outside diameter
Rat and Guinea Pig Heart :
- Left atrial cannula, 2.3 mm outside diameter
Left Atrial and Aortic Flow Measurement :
- Indirect measurement by controlling the pump speed of a roller pump
- Direct measurement using ultrasound transit-time technology
Intracardial Left Ventricular Pressure Measurement :
- Allows introduction of a tip pressure catheter directly into the left ventricle through the adapter port and aorta
- Avoids apical puncture
Pressure-Volume Loop Measurement :
- Allows introduction of a pressure-volume loop catheter directly into the left ventricle through an adapter port and the aorta
Increased Preload Pressure Option :
- Used to create left atrial preload pressures higher than 11 mmHg
- Suitable for high blood pressure-induced disease state simulation
Coronary Effluent Collection :
- Pulmonary artery cannulae
- Preparation dish
- Effluent funnel
- Collection of coronary effluent for metabolic studies and further analysis
- Supports continuous measurement of pO2, pH and pCO2
Perfusate Oxygenation Option :
- Oxygenation of buffer solution supplemented with albumin, fatty acids, washed erythrocytes or other foaming additives
Perfusate Filtration Option :
- Filtration of recirculated perfusate
Temperature Measurement Option :
- Measures perfusate temperature in isolated perfused organ systems
- Useful for specific temperature studies and special temperature protocols such as cooling or transplantation studies
Perfusion Solution Monitoring :
- Continuous or intermittent measurement of pO2, pH and pCO2 in liquid media or perfusate
Drug Addition Option :
- Supports drug addition where flow is measured or calculated and the drug must be added in a specific ratio
Cell Isolation Upgrade :
- Supports cell isolation and cell extraction applications in a working heart system
Pacing Option :
- Provides pacing for functional Langendorff and working heart systems
- Suitable for small rodent hearts including mouse, rat and guinea pig
Single-Lead ECG and MAP Measurement Option :
- Provides single-lead ECG and MAP measurement
- Combines one ECG lead with one MAP electrode
